Phenotype Image Detail

Image

Caption

(E-F) Anaphase bridges and/or lagging chromosomes in Pinx1^tm1.1Kplu/Pinx1⁺ lung and mammary tumors. H&E stained series sections of lung (E) or mammary tumors (F) were examined for anaphase bridges (yellow arrows) and/or lagging chromosomes (red arrows). Original magnification, x100. (G and H) Telomere elongation in Pinx1^tm1.1Kplu/Pinx1⁺ lung cancer cells and mammary cancer cells. Mutant primary lung (G) or mammary (H) cancer cells as well as their respective wild-type normal cells were subjected to qFISH.

This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997

Associated
Alleles

Symbol	Name
Pinx1^tm1.1Kplu	PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu

Associated
Genotypes

Allelic Composition	Genetic Background
Pinx1^tm1.1Kplu/Pinx1⁺	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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