Phenotype Image Detail

Image

Caption

Transverse sections through the thoracic region of wild-type (+/+) (A, C, E) and Ptk7^chz/Ptk7^chz (chz/chz) mice (B, D, F) E17.5 fetuses, stained with hematoxylin and eosin. In control hearts at E17.5, the aorta arises from the left ventricle (A) and the pulmonary trunk arises from the right ventricle (C). In the hearts of mutant littlermates, the aorta (B) and pulmonary trunk (D) arise from the right ventricle, with the vessels rising parallel to one another (B). Whereas the right and left ventricles are separated in the control heart (E), a peri-membranous ventricular septal defect (arrow in F) can be seen in the mutant heart. Ao, aorta; lv, left ventricle; rv, right ventricle; pt, pulmonary trunk.

Copyright

This image is from Paudyal A, BMC Dev Biol 2010;10():87, an open-access article, licensee BioMed Central Ltd. J:163834

Associated Alleles

Symbol	Name
Ptk7^chz	PTK7 protein tyrosine kinase 7; chuzhoi

Associated Genotypes

Allelic Composition	Genetic Background
Ptk7^chz/Ptk7^chz	involves: BALB/cAnN * C3H/HeH