Phenotype Image Detail

Image

Caption

Phalloidin staining of E18.5 organ of Corti from Ptk7^chz/Ptk7⁺ (chz/⁺) (A, C) and Ptk7^chz/Ptk7^chz (chz/chz) mice (B, D), with images from the basal (A, B) or apical (C, D) region of the cochlea. Heterozygous mice show an uniformly polarized orientation of stereociliary bundles in the basal region (A), evident on all three rows of outer hair cells (OHC) and the one row of inner hair cells (IHC). Disruption of bundle orientation was most pronounced in OHC3 of the basal cochlea of mutants (B), with an apparent randomization of bundle orientation; arrowheads indicate misoriented bundles. In apical regions, heterozygous mice demonstrate three rows of OHC and one row of IHC (C). In contrast, hair cell arrangement is disrupted in mutants (D) with a broadened domain of OHC and four apparent rows of cells as well as extra IHC (asterisks).

Copyright

This image is from Paudyal A, BMC Dev Biol 2010;10():87, an open-access article, licensee BioMed Central Ltd. J:163834

Associated Alleles

Symbol	Name
Ptk7^chz	PTK7 protein tyrosine kinase 7; chuzhoi

Associated Genotypes

Allelic Composition	Genetic Background
Ptk7^chz/Ptk7^chz	involves: BALB/cAnN * C3H/HeH