Phenotype Image Detail

Image

Caption

Histology of a Ppcd1/0 mouse eye. Eyes were fixed in 10% formalin in phosphate-buffered saline, processed, and stained with hematoxylin and eosin. Genotypes are indicated at the upper left. D2, DBA/2J; AC, anterior chamber; c, cornea; ce, corneal epithelium; cn, corneal endothelium; Ir, iris; s, synechia. A. Normal eye, age 2.5 months. B. Ppcd1/0 (PPCD1) eye, age 2.5 months. C. Normal iridocorneal angle, age 3 months. D. Mutant iridocorneal angle, age 3 months. Arrowheads indicate multilayered, stratified endotheial cells. E. Normal cornea, age 3 months. F. Mutant cornea showing multilayered, stratified endothelial cells on the posterior surface of the central cornea (arrowhead), age 3 months. G. F4/80 immunohistochemistry of normal cornea, age P19. H. F4/80 immunohistochemistry of mutant cornea, age P19. F4/80-positive cells stained reddish brown. I. Corneal neovascularization (asterisks), age 3 months. J. Anterior synechia, age 5 months.

Copyright

This image is from Shen AL, PLoS One 2010;5(8):, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:164007

Associated Alleles

Symbol	Name
Ppcd1	posterior polymorphous corneal dystrophy 1

Associated Genotypes

Allelic Composition	Genetic Background
Ppcd1/+	D2.129-Ppcd1