Phenotype Image Detail

Image

Caption

X-rays of 6 week-old wild-type (+/+; A, B, C) and Lmna^Dhe/Lmna⁺ (Dhe/+; D,E,F) hemisected skulls. Note lower bone mineral in cranial vault (compare A and D) in the mutant. Total skull length in D is 92% of A (white lines above, A & D). Diastema in E (mandibular arch: the upper white line in B and E) is 67% of that in B, and incisor length in E (the lower white line in B and E) is 87% of that in B. The entire margin of the parietal bone (indicated by white arrows in F) is radiolucent and visible, whereas it cannot be seen C. (G-L), Alizarin red stained skulls of 9 day-old Lmna^Dhe/Lmna^Dhe (Dhe/Dhe). (G,H), heterozygous mutant (I,J) and wild-type (K,L) mice. Overall deficient bone growth and mineralization are evident in homozygous and heterozygous skulls. Right-hand panels are slightly enlarged views of the skulls in the left panels. Note the deficient skull length and failure of mineralization to proceed, especially in the cranial vault, with large, open areas around the parietal and occipital bones (*). Bar in K=9.6 mm in A, D; 4.1 mm in B, E; 0.76 mm in C, F; 2 mm in G, I K; and 0.94 mm in H, J, L.

Copyright

This image is from Odgren PR, PLoS One 2010;5(4):e9959, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160175

Associated Alleles

Symbol	Name
Lmna^Dhe	lamin A; disheveled hair and ears

Associated Genotypes

Allelic Composition	Genetic Background
Lmna^Dhe/Lmna^Dhe	B6(D2)-Lmna^Dhe/TyGrsrJ
Lmna^Dhe/Lmna^+	B6(D2)-Lmna^Dhe/TyGrsrJ