Phenotype Image Detail

Image

Caption

Electron micrographs of day 45 seminiferous tubules reveal abnormal phagocytic membranous wheels in Ehd1^tm1.2Haba/Ehd1^tm1.2Haba (Edh1-/-) mice. (A) In wild-type mice (WT), step 8 round spermatids were found in (B) early stage VIII seminiferous tubules that contained elongated spermatids in the process of spermiation near the lumen with tails apparent after spermiation; box enlarged in (C). (C) A WT elongated spermatid prior to spermiation maintains its ectoplasmic specializations (ES). (D) In Ehd1^tm1.2Haba/Ehd1^tm1.2Haba mice, step 8 round spermatids were found in (E) late stage VIII seminiferous tubules that contained phagocytic membranous wheels engulfing elongated spermatids, their acrosomes and sperm tails; box enlarged in (F).

Copyright

This image is from Rainey MA, BMC Dev Biol 2010;10():37, an open-access article, licensee BioMed Central Ltd. J:160452

Associated Alleles

Symbol	Name
Ehd1^tm1.2Haba	EH-domain containing 1; targeted mutation 1.2, Hamid Band

Associated Genotypes

Allelic Composition	Genetic Background
Ehd1^tm1.2Haba/Ehd1^tm1.2Haba	involves: 129P2/OlaHsd * C57BL/6J * FVB/N