Phenotype Image Detail

Image

Caption

Histologic sections of wild-type (Pax2^+/+) and Pax2^M1Bpb/Pax2^M1Bpb (Pax2^A220G/A220G) mouse kidneys (axial) and cerebellum (sagittal) at E17.5. Whereas wild-type mice have begun to develop renal glomeruli (arrow, A) and tubles (arrowhead, A), the Pax2^M1Bpb/Pax2^M1Bpb mice have only primordial kidneys with poor differentiation of these structures (arrow, B). In contrast, the differentiation of the cerebellum of both wild-type (C) and mutant (D) mice is comparable at this time, despite the midbrain-hindbrain boundary being a site of Pax2 expression during embryogenesis. By E14.5, cranial structure was grossly normal in both wild-type (E) and mutant (F) embryos.

Copyright

This image is from Alur RP, PLoS Genet 2010;6(3):e1000870, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159240

Associated Alleles

Symbol	Name
Pax2^M1Bpb	paired box 2; mutation 1, Brian P Brooks

Associated Genotypes

Allelic Composition	Genetic Background
Pax2^M1Bpb/Pax2^M1Bpb	C57BL/6-Pax2^M1Bpb