Phenotype Image Detail

Image

Caption

Skeletal muscle histology in Fbn2^mz/Fbn2^mz mice. (A) Morphometric analysis of muscle fiber cross-sectional area in the soleus and quadriceps muscles in Fbn2^mz/Fbn2^mz (Mz/Mz, n = 3) and wild-type controls (+/+, n = 3). Two-way ANOVA was not significant. (B) Typical H&E sections of mutant quadriceps muscle from mice at 4 and 9 weeks of age. Scale bar = 100 um. (C) Quantification of central nucleation. The number of muscle fibers with central nuclei is represented as percentage of the total number of muscle fibers analyzed in >100 fibers. Arrows indicate centrally displaced nuclei. Mice were aged 4 weeks and 9 weeks (n = 3 Mz/Mz; n = 3 +/+). P-values (Student's t test): * P<0.05, ** P<0.01.

Copyright

This image is from Miller G, PLoS One 2010;5(2):e9137, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:157998

Associated Alleles

Symbol	Name
Fbn2^mz	fibrillin 2; mariusz

Associated Genotypes

Allelic Composition	Genetic Background
Fbn2^mz/Fbn2^mz	involves: BALB/cAnNCrl * C3H/HeH