Phenotype Image Detail

Image

Caption

(A) Representative appearance of 3-month-old wild-type (+/+), Sos1^tm1.2Rak/Sos1^tm1.2Rak (EK/EK) and Sos1^tm1.2Rak/Sos1⁺ (+/EK) littermates, showing reduced body length and size in the mutant mice. (B) Body weights of wild-type (WT) and mutant male mice with lines fit by linear regression. (P < 0.001 for heterozygous versus WT and P < 0.05 for homozygous versus WT.) (C) Facial defects in 3-month-old mutant mice. Arrowheads indicate blunt noses of mutant mice. (D) CT scans of 3-month-old mice. A sagittal projection (top row) and a coronal projection (bottom row) are shown. Numbers refer to the measurements shown in E. (E) Morphometric characteristics of the mice. Measurements were obtained on the CT sections at the same axial, coronal, and sagittal reference position in all mice (n = 3 for each genotype). Numbers are shown with SD. *P < 0.05, **P < 0.01, ***P < 0.001.

Copyright

This image is from Chen PC, J Clin Invest 2010 Dec 1;120(12):4353-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171873

Associated Alleles

Symbol	Name
Sos1^tm1.2Rak	SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1.2, Raju Kucherlapati

Associated Genotypes

Allelic Composition	Genetic Background
Sos1^tm1.2Rak/Sos1^tm1.2Rak	involves: 129S/Sv * C57BL/6 * FVB/N * SJL
Sos1^tm1.2Rak/Sos1^+	involves: 129S/Sv * C57BL/6 * FVB/N * SJL