Phenotype Image Detail

Image

Caption

A schematic representation of the inner ear (left panels) illustrates the possible positions of the ectopic mineralized bodies as found in a group of Slc26a4^loop/Slc26a4^loop mutant mice. A-F, histological paraffin sections from the vestibular system of P0 mice stained with hematoxylin and eosin. A and B, in wild-type mice, otoconia are restricted to the utricle and saccule, seen as a dense layer of tiny particles over the sensory epithelium. C, other endolymphatic compartments lack any otoconia, as demonstrated with a representative image of a semicircular canal. D and E, in Slc26a4^loop/Slc26a4^loop mutant mice, a giant mineral resides on top of the gravity receptors, utricle and saccule. F, a frequent dislocation of the giant minerallized bodies to the semicircular canals and their cristae is observed. Scale bars equal 75 um in panels A-F, n = 4.

Copyright

This image is from Dror AA, J Biol Chem 2010 Jul 9;285(28):21724-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163655

Associated Alleles

Symbol	Name
Slc26a4^loop	solute carrier family 26, member 4; loop

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a4^loop/Slc26a4^loop	involves: C3HeB/FeJ