Phenotype Image Detail

Image

Caption

Ultrastructural analysis of Sbf2^{Gt(RRF511)Byg}/Sbf2^{Gt(RRF511)Byg} Schwann cells in peripheral nerves. Sciatic nerves from wild-type (WT, C and E) and Sbf2^{Gt(RRF511)Byg}/Sbf2^{Gt(RRF511)Byg} (KO, A,B,D and F) mice were analyzed at 7 months. Ultrathin (70-nm) transverse sections were analyzed by electron microscopy. (A and B) Myelin outfolds in mutant Schwann cells are bounded by the Schwann cell plasma membrane (arrow) and a morphologically normal basal lamina (arrowheads). B is a magnification of the indicated portion of A. (C and D) Myelin periodicity and compaction are normal in mutant nerves. (E and F) Nonmyelinating Schwann cells (white arrowheads) in mutant nerves (F) appear morphologically similar to those in wild-type nerves (E), with nonmyelinated axons segregated from each other and enclosed by interdigitating Schwann cell processes. [Scale bar: 2.2 mm (A), 0.32 mm (B), 44 nm (C and D), 1 mm (E), and 1.75 mm (F).]

Copyright

This image is from Robinson FL, Proc Natl Acad Sci U S A 2008 Mar 25;105(12):4916-21. Copyright 2008 National Academy of Sciences, U.S.A. J:133391

Associated Alleles

Symbol	Name
Sbf2^Gt(RRF511)Byg	SET binding factor 2; gene trap RRF511, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Sbf2^Gt(RRF511)Byg/Sbf2^Gt(RRF511)Byg	involves: 129P2/OlaHsd * C57BL/6