Phenotype Image Detail

Image

Caption

Psoriasis-like skin phenotypes in grafted Cdsn^tm1Mmat/Cdsn^tm1Mmat mouse skin. (A) Many abnormal cellular structures including lipid droplets (L) and remnants of nuclei and organelles (arrows) were observed in the stratum corneum of grafts from Cdsn^tm1Mmat/Cdsn^tm1Mmat (-/-) mice (right). Keratohyalin granules (*, left) were reduced in grafted skin from mutant mice compared with those in the grafted skin from wild-type (+/+) mice. Nu, nucleus. (B) Electron density of each corneodesmosome in grafted skin from mutant mice (right, arrowhead) was markedly lower than that in grafted skin from wild-type mice (left, arrowheads). Formation of cornified cell envelopes was also defective in grafted skin from mutant mice (right, arrows).

Copyright

This image is from Matsumoto M, Proc Natl Acad Sci U S A 2008 May 6;105(18):6720-4. Copyright 2008 National Academy of Sciences, U.S.A. J:134613

Associated Alleles

Symbol	Name
Cdsn^tm1Mmat	corneodesmosin; targeted mutation 1, Mitsuru Matsumoto

Associated Genotypes

Allelic Composition	Genetic Background
Cdsn^tm1Mmat/Cdsn^tm1Mmat	involves: C57BL/6 * CBA