Phenotype Image Detail

Image

Caption

Morphological and histological abnormalities in Ryr1^tm1.1Dhm/Ryr1⁺ mice. (A) Twelve-month old wild-type (WT) and (B) Ryr1^tm1.1Dhm/Ryr1⁺ (IT/+) female littermates. The mutant mouse exhibits dorsal kyphosis and hind limb paresis. Note the flattend posture and outstretched hind limbs that fail to lift the hindquarters. (C-G) NADH-TR-stained longitudinal sections of mutant soleus myofibers from 12-month old (C-E) and 20-month-old (F and G) mice showing minicores and cores. In C-E, arrows show minicores occupying eccentric (C), peripheral (E), and central (D) postiions. In D, the minicore (arrow) shows intense peripheral staining revealing the distorted cross-striation of focally contracted myofibrils. In F and G, the arrows show cores extending longitundinally over multiple sarcomeres. (Scale bars, 10 mm).

Copyright

This image is from Zvaritch E, Proc Natl Acad Sci U S A 2009 Dec 3;():. Copyright 2009 National Academy of Sciences, U.S.A. J:155825

Associated Alleles

Symbol	Name
Ryr1^tm1.1Dhm	ryanodine receptor 1, skeletal muscle; targeted mutation 1.1, David H MacLennan

Associated Genotypes

Allelic Composition	Genetic Background
Ryr1^tm1.1Dhm/Ryr1^+	involves: 129S2/SvPasCrl * 129S6/SvEvTac