Phenotype Image Detail

Image

Caption

Myocardial lesions appeared in Cxadr^tm1Rwf/Cxadr^tm1Rwf embryos ~10.8 dpc. These are hematoxylin and eosin-stained sections of hearts from 10.8-11 dpc embryos at 100x magnification. a: Heart of a typical Cxadr^tm1Rwf/Cxard⁺ (+/-) embryo. No abnormalities are apparent. b-d: Hearts from three representative Cxadr^tm1Rwf/Cxadr^tm1Rwf (-/-) embryos. Each of these exhibited myocardial lesions (green squares). Lesions were characterized by dark red, eosinophilic cells with condensed nuclei in the center of the myocardium and swollen, anuclear cells at the periphery. The location of the cardiac lesions was variable. Embryo (b) had lesions on the dorsal sides of the atrium and ventricle. Embryo (c) had lesions on the dorsal and ventral sides of the ventricle. The nucleated fetal erythrocytes present in the pericardial space suggested that blood was escaping the heart. Embryo (d) showed more extensive lesions throughout the myocardium and disruption of the ventricle wall.

Copyright

This image is from Asher DR, Genesis 2005 Jun;42(2):77-85, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:99585

Associated Alleles

Symbol	Name
Cxadr^tm1Rwf	coxsackie virus and adenovirus receptor; targeted mutation 1, Robert W Finberg

Associated Genotypes

Allelic Composition	Genetic Background
Cxadr^tm1Rwf/Cxadr^tm1Rwf	involves: 129S6/SvEvTac * C57BL/6