Phenotype Image Detail

Image

Caption

Fgf15^tm1Sms/Fgf15^tm1Sms mice display cardiovascular defects consistent with pharyngeal arch dysfunction; heart phenotypes at E18.5. a,a': An anterior view of the heart with the atria and great vessels removed shows that Fgf15^tm1Sms/Fgf15^tm1Sms (-/-) mice display outflow tract malalignment relative to wild-type (WT). b-b''': Mutant hearts display membranous ventricular septal defects (arrows in b'-b'''), overriding aorta (b'') and double outlet right ventricle (b'''). c,c': Mutant hearts display muscular ventricular septal defects (arrow in c'). Ao, aorta; PT, pulmonary trunk; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; RAV, right atrio-ventricular canal; LAV, left atrio-ventricular canal. Scale bar= 1mm.

Copyright

This image is from Vincentz JW, Genesis 2005 Apr;41(4):192-201, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:97317

Associated Alleles

Symbol	Name
Fgf15^tm1Sms	fibroblast growth factor 15; targeted mutation 1, Suzanne L Mansour

Associated Genotypes

Allelic Composition	Genetic Background
Fgf15^tm1Sms/Fgf15^tm1Sms	involves: 129S1/Sv * 129X1/SvJ * C57BL/6