Phenotype Image Detail

Image

Caption

Phenotypic abnormalities in the liver of Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} mice. A and B, beyond an age of 7 months, Cers2^{Gt(S16-4B1)Sor}/Cers2^{Gt(S16-4B1)Sor} (gt/gt) mice regulary featured multiple hepatic tumors, macroscopically appearing as gray nodules, throughout the liver parenchyma, in extreme cases (A) extending through a major part of the otherwise dark brown organ. The histological appearance of the tumor cells is that of pale hepatocytes, often filled with large lipid droplets (C). The white line indicates the separation of tumor tissue (right) and normal hepatocytes (left). Note that the normal architecture of liver lobules with central veins (asterisks) and radial sinusoids is lost in tumor tissue (C-E). The key ultrastructural hallmarks of liver tissue, Disse spaces, and bile canaliculi (arrowhead and arrow in F) are no longer discernible in tumor tissue (Disse space and bile canaliculi shown by white circles in G and H for wild-type tissue; endothelia-like cells directly attached to hepatocytes and disfigured vacuolar structures in place of bile canaliculi shown by white circles in I, J for mutant tissue). Calibration bars, 500 um in C, 100 um in D and E, 5 um in F, 10 um in G, 1 um in H, 10 um in I and 3 um in J.

Copyright

This image is from Imgrund S, J Biol Chem 2009 Nov 27;284(48):33549-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156841

Associated Alleles

Symbol	Name
Cers2^Gt(S16-4B1)Sor	ceramide synthase 2; gene trap S16-4B1, Philippe Soriano

Associated Genotypes

Allelic Composition	Genetic Background
Cers2^Gt(S16-4B1)Sor/Cers2^Gt(S16-4B1)Sor	involves: 129S4/SvJaeSor * C57BL/6