Phenotype Image Detail

Image

Caption

Electron micrographs of degenerating spermatids. Sections of Rsph1^tm1Htan/Rsph1^tm1Htan (-/-) testis are shown. A, spermatids in a stage VI seminiferous tubule. Step 15 spermatids show deformation of the heads (arrow) and numerous vacuoles (*) in the cytoplasm. Flagella (F) that contain an axoneme, mitochondria, outer dense fibers, and fibrous sheaths are formed; however, these components are disarranged in the cytoplasm. Step 6 spermatids (S6) appear to be normal in shape. B, spermatid phagocytosed by Sertoli cells (S). The highly deformed nucleus/head (N), acrosome (*), and mitochondrial sheath (M) of the spermatids are shown.

Copyright

This image is from Tokuhiro K, J Biol Chem 2008 Jul 4;283(27):19039-48 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:138122

Associated Alleles

Symbol	Name
Rsph1^tm1Htan	radial spoke head 1 homolog (Chlamydomonas); targeted mutation 1, Hiromitsu Tanaka

Associated Genotypes

Allelic Composition	Genetic Background
Rsph1^tm1Htan/Rsph1^tm1Htan	involves: 129S1/Sv * C57BL/6J