Phenotype Image Detail

Image

Caption

Morphological and histological analyses of wild-type (NTG) and Tg(Myh6-AIP/PLN*)46Jded/0 (TG) mouse hearts. A: Representative example of female mouse hearts at 7 months of age after delivering at least three litters. Note the massive enlargement of the left atrium and ventricle in transgenic mice. Bar, 12 mm. B and C: Paraffin-embedded thin sections of mutant and age-matched controls were stained with hematoxylin and eosin. B: Enlargement of the left cardiac chambers is evident, especially left atrium. Atrial thrombi are frequently observed. C: High magnification (x40 microscope objective) of the septum. Increased myocyte hypertrophy and disarray and intracellular spacing are found in the mutant ventricles.

Copyright

This image is from Ji Y, J Biol Chem 2003 Jul 4;278(27):25063-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:84333

Associated Alleles

Symbol	Name
Tg(Myh6-AIP/PLN*)46Jded	transgene insertion 46, John R Dedman

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Myh6-AIP/PLN*)46Jded/0	FVB/N-Tg(Myh6-AIP/PLN*)46Jded