Phenotype Image Detail

Image

Caption

Histology of the testis. 5-um sections of testis from a wild-type male (A) and Clcn2^tm1Mlv/Clcn2^tm1Mlv male (B) obtained 10 weeks after birth. The normal testicular architecture found in the wild-type male is compromised in the mutant mouse, with missing germ cell layers (double-headed arrow in the wild-type), abnormal Sertoli cells (small arrows) and a relative hyperplasia of the Leydig cells (large arrows).

Copyright

This image is from Nehrke K, J Biol Chem 2002 Jun 28;277(26):23604-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:77673

Associated Alleles

Symbol	Name
Clcn2^tm1Mlv	chloride channel, voltage-sensitive 2; targeted mutation 1, James E Melvin

Associated Genotypes

Allelic Composition	Genetic Background
Clcn2^tm1Mlv/Clcn2^tm1Mlv	involves: C57BL/6