Phenotype Image Detail

Image

Caption

Selected fetal views demonstrating the absence of cardiovascular and craniofacial defects in Ecel1^tm1Jroh/Ecel1^tm1Jroh mice. A and B, gross photographs of the great vessels from E18.5 wild-type (+/+, A) and Ecel1^tm1Jroh/Ecel1^tm1Jroh (-/-, B) embryos. A, aortic arch; da, ductus arteriosus; lc, left carotid; ls, left subclavia; rc, right carotid; rs, right subclavia; Pt, pulmonary trunk; t, trachea. C and D, alizarin-stained skeleton preparations of fetal heads from E18.5 wild-type (C) and mutant (D) mice. M, mandible; b, basisphenoid; h, hyoid; o, odontoid; t, thyroid cartilage. The presence or absence of eye pigmentation is incidental in the two mice and not related to the gene disruption. The blue color in D is the remnant of an incomplete Alcian blue staining.

Copyright

This image is from Schweizer A, J Biol Chem 1999 Jul 16;274(29):20450-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:56300

Associated Alleles

Symbol	Name
Ecel1^tm1Jroh	endothelin converting enzyme-like 1; targeted mutation 1, Jack Rohrer

Associated Genotypes

Allelic Composition	Genetic Background
Ecel1^tm1Jroh/Ecel1^tm1Jroh	involves: 129P2/OlaHsd * C57BL/6