Phenotype Image Detail

Image

Caption

A: Hematoxylin and eosin stained kidney sections from a 6 week old Lin7c^tm1Dsb/Lin7c^tm1Dsb (-/-) mouse. Low magnification image shows dilated tubules and cysts in cortex and outer medulla. Higher magnification of kidney section from a mutant shows cyst (arrow). B: Kidney section from mutant labeled with Dolichos biflorus agglutinin (DBA, red) or Lotus lectin (LL, green). C: Hematoxylin and eosin stained kidney sections from P0 mutant pup shows many of the same pathological features of kidneys from adult mutant, including fibrosis (D, arrow). E: Urine concentrating ability, measured as the response to 12-hour water deprivation and vasopressin injection after a high water load, is impaired in mutant mice.

Copyright

This image is from Olsen O, J Cell Biol 2007 Oct 8;179(1):151-64, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:134806

Associated Alleles

Symbol	Name
Lin7c^tm1Dsb	lin-7 homolog C, crumbs cell polarity complex component; targeted mutation 1, David S Bredt

Associated Genotypes

Allelic Composition	Genetic Background
Lin7c^tm1Dsb/Lin7c^tm1Dsb	involves: 129S1/Sv * 129X1/SvJ