Phenotype Image Detail

Image

Caption

Ultrastructure of central nervous system (CNS) and peripheral nervous system (PNS) nodes of Ranvier (NR) in wild-type (+/+) and Sptbn4^tm1Msol/Sptbn4^tm1Msol (-/-) mice. EM of the optic (A-D) and sciatic (E-K) nerves from adult wild-type (A,B,E and F) and mutant (C,D and G-K). Arrows and insets show the coat beneath the NR membrane. Arrowheads show the protrusions in the NR of mutant mice. (L) Ratio between the width of each NR and its corresponding juxtaparanodes. Errors are given as mean +/- SEM. ***, P<0.001. Bars: (A,C and I-K) 1 um; (E and G) 2 um; (B,D,F and H) 125 nm.

Copyright

This image is from Lacas-Gervais S, J Cell Biol 2004 Oct 27;166(7):983-90, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:93411

Associated Alleles

Symbol	Name
Sptbn4^tm1Msol	spectrin beta, non-erythrocytic 4; targeted mutation 1, Michele Solimena

Associated Genotypes

Allelic Composition	Genetic Background
Sptbn4^tm1Msol/Sptbn4^tm1Msol	involves: C57BL/6