Phenotype Image Detail

Image

Caption

Electron micrographs of the labyrinth of E11.5 Syna^tm1.1Ics/Syna^tm1.1Ics placenta in a region where the interhemal barrier is not formed but discloses normal development of the ST-II syncytiotrophoblast layer (a; expanded view in b). The ST-II layer (with typical lipid inclusions, asterisks) interacts-with membrane boundaries of normal appearance-with the endothelial cells (ec) of the fetal blood vessels (frbs, fetal red blood cells), and on the other side with undifferentiated mononuclear trophoblast cells arranged as a parenchyma. The latter are most probably ectoplacental cells (epc), as can be inferred from their large nuclei and lack of lipid vesicles, and are presumed to finally differentiate into the ST-I syncytiotrophoblast layer in normal placenta. Scale bar: 2 um.

Copyright

This image is from Dupressoir A, Proc Natl Acad Sci U S A 2009 Jul 21;106(29):12127-32. Copyright 2009 National Academy of Sciences, U.S.A. J:150813

Associated Alleles

Symbol	Name
Syna^tm1.1Ics	syncytin a; targeted mutation 1.1, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Syna^tm1.1Ics/Syna^tm1.1Ics	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL