Phenotype Image Detail

Image

Caption

A: Summary of cancer incidents and cancer rate in wild-type and Becn1^tm1Htz/Becn1⁺ mice (age and gender matched). B and C: B cell lymphoma. B: Hematoxylin and eosin staining of tumor tissue. C: Immunohistochemical staining of the same tumor in b with antibody against B220 (B cell marker). D-F: Heptocellular carcinoma. D: Hematoxylin and eosin staining of liver tissue containing heptocellular carcinoma. Note the upper portion showing normal tissue and the lower portion showing tumor. E and F: High magnitude of normal and tumor tissue, respectively, in d. G: Lung adenocarcinoma; Hematoxylin and eosin staining showing tumor, (left portion) and normal (right portion) tissue of the lung. Scale bar, 50um.

Copyright

This image is from Yue Z, Proc Natl Acad Sci U S A 2003 Dec 9;100(25):15077-82. Copyright 2003 National Academy of Sciences, U.S.A. J:86982

Associated Alleles

Symbol	Name
Becn1^tm1Htz	beclin 1, autophagy related; targeted mutation 1, Nathaniel Heintz

Associated Genotypes

Allelic Composition	Genetic Background
Becn1^tm1Htz/Becn1^+	involves: 129P2/OlaHsd * C57BL/6