Phenotype Image Detail

Image

Caption

A: Slc39a13^tm1Thir/Slc39a13^tm1Thir (KO) mice develop abnormal incisor teeth (upper). 5 week-old mutant mice show evidence of malocclusion (red arrowhead), deformity (blue arrowhead), and breakage (yellow arrowhead) of incisor teeth. Lower panels show 3D m-CT imaging analysis showing a systemic decrease in bone density and abnormal tooth development of 5 week old mutant mice compared with wild-type (WT) littermates. B: Craniofacial features of mutant mouse. Eye shows enophthalmos-like appearance and downslanting palpebral fissures in mutant mouse. Representative face images of 5 week old wild-type and mutant mouse. C: Root dentin formation of molar teeth (red arrowhead) and the bone volume fraction of mandible (yellow arrowhead) are remarkably reduced in mutant mice. BEN (upper) and 3D m-CT images (lower) of mandibular molar regions in 5 week old wild-type and mutant mice are shown. D: Root dentin and alveolar bone are reduced in mutant mice. Sagittal sections of mandibular molar regions in 5 week old wild-type and mutant mice were stained with Hematoxylin and Eosin. Boxed areas are reproduced at higher magnification. de, dentin; ab, alveolar bone.

Copyright

This image is from Fukada T, PLoS ONE 2008;3(11):e3642, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:143911

Associated Alleles

Symbol	Name
Slc39a13^tm1Thir	solute carrier family 39 (metal ion transporter), member 13; targeted mutation 1, Toshio Hirano

Associated Genotypes

Allelic Composition	Genetic Background
Slc39a13^tm1Thir/Slc39a13^tm1Thir	involves: 129S1/Sv * 129X1/SvJ