Phenotype Image Detail

Image

Caption

Histology of thymus of Zeb1^tm1Yhi/Zeb1^tm1Yhi mice. Thymi of 6 week old Zeb1^tm1Yhi/Zeb1⁺ (A and C) and Zeb1^tm1Yhi/Zeb1^tm1Yhi (B and D) mice were fixed in Bouin's fixative and stained with hematoxylin and eosin. The heterozygous thymus had developed distinct medulla and cortex (A), while mutant thymi had uniform parenchyma with light staining as seen in medulla of the heterozygous thymus (B). Note also the differences of size and cellularity between them. The heterozygous thymus had a typical cortex which consists of the densely packed and actively proliferating small thymocytes as shown in higher magnification (C), while the mutant thymus seemed to lack its architecture (D). Bars: A and B, 200 um; C and D, 40 um.

Copyright

This image is from Higashi Y, J Exp Med 1997 Apr 21;185(8):1467-79, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:39865

Associated Alleles

Symbol	Name
Zeb1^tm1Yhi	zinc finger E-box binding homeobox 1; targeted mutation 1, Yujiro Higashi

Associated Genotypes

Allelic Composition	Genetic Background
Zeb1^tm1Yhi/Zeb1^tm1Yhi	B6.129P2-Zeb1^tm1Yhi