Phenotype Image Detail

Image

Caption

Scanning electron microscopy of erupted mouse incisors and molars at 7 weeks. Scanning electron microscopy (SEM) was used to examine fractured sections of mouse incisors (A-D) and molars (E-H). The enamel of wild-type (Enam^+/+; A and E) and Enam^tm1.1Jcch/Enam⁺ (Enam^+/-; B and F) mice both showed a thick enamel layer with well defined rod (prism) structures. In contrast, the enamel of Enam^tm1.1Jcch/Enam^tm1.1Jcch (Enam^-/-; C,D,G and H) mice was extremely thin and irregular, with a rough surface. In some places (G), the enamel did not even form sufficiently to complete the dentino-enamel junction (DEJ). Arrowheads delineate the DEJ.

Copyright

This image is from Hu JC, J Biol Chem 2008 Apr 18;283(16):10858-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:136524

Associated Alleles

Symbol	Name
Enam^tm1.1Jcch	enamelin; targeted mutation 1.1, Jan C C Hu

Associated Genotypes

Allelic Composition	Genetic Background
Enam^tm1.1Jcch/Enam^tm1.1Jcch	C57BL/6-Enam^tm1.1Jcch
Enam^tm1.1Jcch/Enam^+	C57BL/6-Enam^tm1.1Jcch