Phenotype Image Detail

Image

Caption

Myofibrillar ultrastructure in the developing atrial myocardium of wild-type (WT, A,C and E) and Calr^tm1Mlk/Calr^tm1Mlk (KO, B,D and F) hearts. Magnification 10,000x. In atrial myocardium, there was no difference between the degree of organization following myofibrillar disarray between the calreticulin phenotypes. Atrial myocardium of both phenotypes contains large amounts of cytosol. Consequently, the myofibrillar arrangement of the atrial myocardium is less compact compared to the corresponding ventricular myocardial tissue (A,B,C,D,E and F). By 18.5 dpc, most of the wild-type and mutant myofibrils of atrial myocardium run in straight courses aligned parallel to each other with their Z-lines in register (E and F).

Copyright

This image is from Lozyk MD, BMC Dev Biol 2006;6():54, an open-access article, licensee BioMed Central Ltd. J:119647

Associated Alleles

Symbol	Name
Calr^tm1Mlk	calreticulin; targeted mutation 1, Marek Michalak

Associated Genotypes

Allelic Composition	Genetic Background
Calr^tm1Mlk/Calr^tm1Mlk	involves: 129S4/SvJae * C57BL/6J