Phenotype Image Detail

Image

Caption

Electron micrograph of wild-type and Lama3^tm1Crt/Lama3^tm1Crt skin. A and B show the ultrastructure of wild-type mouse skin. A: Hemidesmosomes (HDs) [hd] are clearly defined in wild-type mouse skin. B: Higher magnification shows the outer and inner electron dense plaque of the HDs with keratin filaments (k) running toward the HDs. Beneath the HDs is the basement membrane zone (BMZ), which contains laminin 5. The mutant skin (C and D) contains rudimentary HDs (rhd) that are not well-defined. Higher magnification (inset in D) shows that HDs in mutant skin are more diffuse and less well-defined.

Copyright

This image is from Ryan MC, J Cell Biol 1999 Jun 14;145(6):1309-23, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55865

Associated Alleles

Symbol	Name
Lama3^tm1Crt	laminin, alpha 3; targeted mutation 1, William G Carter

Associated Genotypes

Allelic Composition	Genetic Background
Lama3^tm1Crt/Lama3^tm1Crt	involves: 129 * C57BL/6J