Phenotype Image Detail

Image

Caption

Normal (A) and Lama3^tm1Crt/Lama3^tm1Crt (mutant, B and C) skin was fixed in 4% formalin, paraffin embedded, and sections were stained with hematoxylin and eosin. C: A junctional blister present in the mutant skin that is characterized by a separation of the epidermis (e) from the dermis (d) at the basement membrane zone (BMZ). Basal cells in the lesion appear sparse and flattened (arrows). Arrows with asterisks mark cell clusters that appear undifferentiated in the superbasal cell layer (C).

Copyright

This image is from Ryan MC, J Cell Biol 1999 Jun 14;145(6):1309-23, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55865

Associated Alleles

Symbol	Name
Lama3^tm1Crt	laminin, alpha 3; targeted mutation 1, William G Carter

Associated Genotypes

Allelic Composition	Genetic Background
Lama3^tm1Crt/Lama3^tm1Crt	involves: 129 * C57BL/6J