Phenotype Image Detail

Image

Caption

Mandible development in Gja1^tm1Kdr/Gja1^tm1Kdr mice. Alizarin red/alcian blue staining of the mandibles at E18.5 (A and B) and at birth (C and D) of wild-type (WT) and Gja1^tm1Kdr/Gja1^tm1Kdr (Cx43^-/-) littermates. In newborn mutants, the mandible was smaller, with a more rounded alveolar ridge and flatter arch. This malformation contributes to the slightly smaller and more pointed snout in mutant mice. In some mutant newborn mice, cartilaginous primordia of the temporal bone and the condylar region of the mandible were still present at birth (D). Note, (B, arrow) the lack of the inscisor tooth at E18.5 in the mutant embryo and (D) the less prominent tooth at birth. Also, note the less pronounced alveolar ridge (AR) in the mutant mice and the cartilaginous coronoid process (CP).

Copyright

This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866

Associated Alleles

Symbol	Name
Gja1^tm1Kdr	gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder

Associated Genotypes

Allelic Composition	Genetic Background
Gja1^tm1Kdr/Gja1^tm1Kdr	involves: 129S1/Sv * 129X1/SvJ * C57BL