Phenotype Image Detail

Image

Caption

Transmission electron microscopy analysis of skeletal muscle cells (upper panels) and neighboring endothelial cells (lower panels) from wild-type (Cav-3 WT, left panels) and Cav3^tm1Mls/Cav3^tm1Mls (Cav-3 KO, right panels) are shown. Note that a lack of caveolin-3 expression in mutant mice results in an absence of caveolae at the sarcolemma (muscle cell plasms membrane). As expected, caveolae are still present in endothelial cells from wild-type and mutant mice.

Copyright

This image is from Galbiati F, J Biol Chem 2001 Jun 15;276(24):21425-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:69965

Associated Alleles

Symbol	Name
Cav3^tm1Mls	caveolin 3; targeted mutation 1, Michael P Lisanti

Associated Genotypes

Allelic Composition	Genetic Background
Cav3^tm1Mls/Cav3^tm1Mls	involves: 129/Sv * C57BL/6J * SJL
Cav3^tm1Mls/Cav3^tm1Mls	FVB.Cg-Cav3^tm1Mls