Phenotype Image Detail

Image

Caption

Dgat2^tm1Far/Dgat2^tm1Far (-/-) epidermis exhibited reduced numbers of lamellar membranes in the stratum corneum extracellular spaces (A, arrows) compared with wild-type (+/+) epidermis (B), reduced lamellar body contents (C, arrowheads) compared with the wild-type epidermis (D), and abnormalities in the secreted contents at the stratum granulosum-stratum corneum interface (E, arrow). A,B,D, and E, ruthenium tetroxide staining post-fixation; C, osmium tetroxide staining post-fixation. Bar is 0.25um.

Copyright

This image is from Stone SJ, J Biol Chem 2004 Mar 19;279(12):11767-76 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88742

Associated Alleles

Symbol	Name
Dgat2^tm1Far	diacylglycerol O-acyltransferase 2; targeted mutation 1, Bob Farese

Associated Genotypes

Allelic Composition	Genetic Background
Dgat2^tm1Far/Dgat2^tm1Far	involves: 129S4/SvJae * C57BL/6J