Phenotype Image Detail

Image

Caption

Defects in water barrier of Elovl3^tm1Jaco/Elovl3^tm1Jaco mice. A: 20 min after a 2-min swin in 30 degree celsius, Elovl3^tm1Jaco/Elovl3^tm1Jaco mice (left) are still wet compared with wild-type mice (right). B: Impaired water repulsion in mutant mice. Mutant mice absorb more water during swim than wild-type mice. Error bars indicate mean +/- S.E. of seven wild-type and mutant mice, respectively. C: Increased water absorption induces hypothermia in mutant mice compared with wild-type mice. After exposure to water, rectal temperature was measured every 5 min for one hour. Each point is mean +/- S.E. in four experiments. D: Impaired skin barrier in mutant mice because of trans-epidermal water loss in healthy wild-type mice (+/+) and mutant (-/-). The values are expressed as mean +/- S.E. of 10 mice in each group. p = <0.01 in comparison with healthy mice.

Copyright

This image is from Westerberg R, J Biol Chem 2004 Feb 13;279(7):5621-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88477

Associated Alleles

Symbol	Name
Elovl3^tm1Jaco	ELOVL fatty acid elongase 3; targeted mutation 1, Anders Jacobsson

Associated Genotypes

Allelic Composition	Genetic Background
Elovl3^tm1Jaco/Elovl3^tm1Jaco	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J