Phenotype Image Detail

Image

Caption

Macroscopic and histological examination reveals phenotypic alterations of testis from Pafah1b1^{Gt(IRESBetageo)1Hha}/Pafah1b1^{Gt(IRESBetageo)1Hha} mice. A: Testis size is severely reduced (50% of wild-type) in Pafah1b1^{Gt(IRESBetageo)1Hha}/Pafah1b1^{Gt(IRESBetageo)1Hha} (panels a and b) mice. Sections through epididymis demonstrate tubules of smaller diameter that are devoid of spermatozoa in the mutant (panel c). B: Histological sections through testes from mutant mice at postnatal days 15 (a), 25 (b), 35 (c). 45 (d), and 90 (e). Control section of wild-type testis at postnatal day 90 is shown for comparison (f). Note the fairly normal appearance of germ cells in the mutant until day 45 after birth with spermatocytes and spermatids present in seminiferous tubules (a-d). However, at day 90 the tissue architecture appears grossly disturbed in the mutant, and spermatids are clustered instead of lining the luminal epithelium of the seminiferous tubules (e). In contrast to wild type testis (f), no spermatozoa are present in the mutant.

Copyright

This image is from Nayernia K, J Biol Chem 2003 Nov 28;278(48):48377-85 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:86720

Associated Alleles

Symbol	Name
Pafah1b1^Gt(IRESBetageo)1Hha	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; gene trap 1, Hans-Henning Arnold

Associated Genotypes

Allelic Composition	Genetic Background
Pafah1b1^Gt(IRESBetageo)1Hha/Pafah1b1^Gt(IRESBetageo)1Hha	involves: 129/Sv * NMRI