Phenotype Image Detail

Image

Caption

Frontal sections of placenta from E12.5 wild-type and Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr embryos. A: Hematoxylin and eosin staining of wild-type placenta shows labyrinth region (La) with extensive well developed fetal vessels surrounded by blood sinuses containing enucleated maternal erythrocytes. The spongiotrophoblast layer (Sp) is distinct in wild-type placenta. B: In Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr placenta, maternal blood sinuses are generally absent in most areas of labyrinth zone. No organized spongiotrophoblast layer is present. C and D: Close up view of labyrinth region shows cells with multinucleus clusters in mutant placenta (black arrowhead). Cellularization is less extensive compared with the control. Nucleated fetal erythrocytes in mutant placenta (black arrow) exhibit irregularly shaped nuclei and have scant cytoplasm compared with control.

Copyright

This image is from Zhu YJ, J Biol Chem 2003 Jan 17;278(3):1986-90 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:81217

Associated Alleles

Symbol	Name
Ncoa6^tm1.1Jkr	nuclear receptor coactivator 6; targeted mutation 1.1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1.1Jkr/Ncoa6^tm1.1Jkr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N