Phenotype Image Detail

Image

Caption

Pathological changes in Slc19a1^tm1Gold/Slc19a1^tm1Gold mice born from heterozygous dams supplemented with folic acid. A: Reduced growth of a Slc19a1^tm1Gold/Slc19a1^tm1Gold mouse (left) compared with wild-type (middle) and Slc19a1^tm1Gold/Slc19a1⁺ (right) littermates at day 9 postpartum. B: Marked reduction in the size of thymus (left) and spleen (right) and pale color of these two organs and the liver (middle) from 9 day old mutant mice (bottom) compared with organs from wild-type mice (top) are noted. Sections of bone marrow of a mutant mouse demonstrating severe reduction in hematopoietic cells (C) as compared with the densely populated marrow (arrow) in a wild-type littermate (D). The spleen in mutant mice (E) shows almost complete loss of erythropoiesis in the red pulp (RP) compartment and marked reduction in lymphoid cells in the white pulp (WP), whereas wild-type mice (F) show well developed white pulp and large numbers of nucleated differentiating red blood cells series in the red pulp. The cortex (C) of the thymus of mutant mice is markedly reduced in thickness and virtually depleted of small lymphocytes with dark staining nucleus (G). The thymus of the wild-type mice at this stage shows a dense lymphocytic population in the cortex (C) with distinct delineation from the medulla (M) (H).

Copyright

This image is from Zhao R, J Biol Chem 2001 Mar 30;276(13):10224-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:68666

Associated Alleles

Symbol	Name
Slc19a1^tm1Gold	solute carrier family 19 (folate transporter), member 1; targeted mutation 1, I David Goldman

Associated Genotypes

Allelic Composition	Genetic Background
Slc19a1^tm1Gold/Slc19a1^tm1Gold	involves: 129/Sv * C57BL/6 * SJL