Phenotype Image Detail

Image

Caption

A: Vibratone sections were prepared from cerebella of Nrcam^tm1Gmt/Nrcam^tm1Gmt L1cam^tm1Sor/Y (Nr-/-L1-/y) mouse and its littermate. Top panels are P6 cerebella stained with cresyl violet. Some fissures are missing or less well developed in double mutant mice compared with littermates. Note that although the size of cerebellum is smaller in the double mutant mouse, the size of the brain stem is similar to that of littermate controls. Bottom panels are magnified views of top panels. Note that in comparable regions within the folia, the IGL is thinner in the double mutant than in the littermate control (arrows). Bars, 640um (top) and 160um (bottom). B: Frontal vibratone sections were prepared from brain of double mutant mouse and its littermate at P5. Top and middle panels were stained with antineurofilament antibody following Nissl staining. Magnified views of hippocampal regions of top panels are shown in the middle panels. Although brain size is smaller, overall structures including hippocampus are similar between the double mutant mouse and their littermate. Bottom panels show layer formation in cortex of double mutant mouse and its littermate visualized by Nissl staining on vibratone sections. Layer formation in cortex appears normal in double mutant mice. Bar: (top) 400um; (others) 200um.

Copyright

This image is from Sakurai T, J Cell Biol 2001 Sep 17;154(6):1259-73, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:71828

Associated Alleles

Symbol	Name
L1cam^tm1Sor	L1 cell adhesion molecule; targeted mutation 1, Philippe Soriano
Nrcam^tm1Gmt	neuronal cell adhesion molecule; targeted mutation 1, Martin Grumet

Associated Genotypes

Allelic Composition	Genetic Background
L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster