Phenotype Image Detail

Image

Caption

Epiphyseal growth plate chondrodystrophy in priximal tibia of Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc (ko) mice. Arrowheads denote the approximate lower limit of the proliferative chondrocyte zone and arrows the lower limit of the hypertrophic zone, the distance between thus being the thickness of the hypertrophic zone. Wild type mice (wt) show a normal growth plate, with columns of chondrocytes underdoing proliferation and differentiation to hypertrophy in the lower region, followed by remodeling of cartilage into metaphyseal bone and the formation of a marrow cavity (m). Mutant mice display abnormal chondrocyte organization and differentiation, with a reduced proliferating zone (arrowhead) and a thickened zone of hypertrophy, resulting in an increase in overall thickness of the growth plate. Magnification x800. Toluidine-blue-stained, demineralized, Epon-embedded 1um sections.

Copyright

This image is from Kim N, Proc Natl Acad Sci U S A 2000 Sep 26;97(20):10905-10. Copyright 2000 National Academy of Sciences, U.S.A. J:64737

Associated Alleles

Symbol	Name
Tnfsf11^tm1Ywc	tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi

Associated Genotypes

Allelic Composition	Genetic Background
Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc	involves: 129P2/OlaHsd