Phenotype Image Detail

Image

Caption

Podocytes in newborn Lmx1b^tm1Rjo/Lmx1b^tm1Rjo mice do not spread out over the glomerular basement membrane (GBM) (arrows) but retain a cuboidal shape (a). In many areas the GBM was split (b shows a transition between a one-layered GBM marked by arrows and a split GBM marked by arrowheads). In no glomerulus did we notice foot processes and slit diaphragms, but adjacent podocytes were connected by structures resembling adherens junctions (c; note the cytoplasmic plaques outlined by arrows on either side of the junction). In some glomeruli we also observed erythrocytes (E) and fibrillar material (arrows) in Bowman's space (d), which upon higher magnification showed a striated pattern reminiscent of fibrin (e). Bar: a, 2um; b and d, 1um; c and e, 100nm.

Copyright

This image is from Rohr C, J Clin Invest 2002 Apr;109(8):1073-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:76088

Associated Alleles

Symbol	Name
Lmx1b^tm1Rjo	LIM homeobox transcription factor 1 beta; targeted mutation 1, Randy L Johnson

Associated Genotypes

Allelic Composition	Genetic Background
Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: C57BL/6