Phenotype Image Detail

Image

Caption

A: Distribution of genotypes in the Prss8^tm1.2Hum/Prss8^tm1.1Hum Tg(KRT14-cre)1Ipc/0 mice (lox/deltaCre+, black bar) and control (Ctrl) groups (white, light gray and dark gray bars) at birth indicated in percentages. From a total of 131 pups (n=14 litters) that were analyzed shortly after birth, 28 were from the knockout group, 32 were from Prss8^tm1.2Hum/Prss8⁺, 40 were from Prss8^tm1.2Hum/Prss8^tm1.1Hum, and 31 were from Prss8^tm1.2Hum/Prss8^tm1.1Hum Tg(KRT14-cre)1Ipc/0 mice (control group; expected distribution in percentage; dotted line). ***, P < 0.001. B: Survival curves of mutant (black squares) and control mice (white diamonds and gray squares). Note that no mutant mice survived 60 hours after birth. C: Representative example showing different sized of mutant (right) and control (left) littermates. D: Representative skin sections from newborn control (top) and mutant (bottom) littermates stained with hematoxylin and eosin. Staining (left) shows abnormal stratum corneum (SC) formation and a reduced hair follicle number in the mutant skin. Higher magnification (right) reveals an orthokeratotic hyperkeratosis and dysmaturation of hair follicles.

Copyright

This image is from Leyvraz C, J Cell Biol 2005 Aug 1;170(3):487-96, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:100139

Associated Alleles

Symbol	Name
Prss8^tm1.1Hum	serine protease 8 (prostasin); targeted mutation 1.1, Edith Hummler
Prss8^tm1.2Hum	serine protease 8 (prostasin); targeted mutation 1.2, Edith Hummler
Tg(KRT14-cre)1Ipc	transgene insertion 1, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Prss8^tm1.1Hum/Prss8^tm1.2Hum Tg(KRT14-cre)1Ipc/0	involves: 129/Sv * C57BL/6 * FVB/N * SJL