Phenotype Image Detail

Image

Caption

Histological lung analysis of wild type and Robo1^tm1Phr/Robo1^tm1Phr littermates. Paraformaldehyde-fixed 4um sections of lung tissue were hematoxylin and eosin stained and photographed. A: Wild type (+/+) lung, embryo day 15.5 (x400). B: Robo1^tm1Phr/Robo1^tm1Phr (-/-) lung, embryo day 15.5 (x400). C: Wild type newborn lung (x100). D: Mutant newborn lung (x100, arrows indicate bronchi). E: Wild type adult lung (x100). F: Mutant adult lung (x100). G: Wild type adult lung (x400). H: Mutant adult lung (x400). I: Mutant adult lung (x400, focal dysplasia indicated by arrow).

Copyright

This image is from Xian J, Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15062-6. Copyright 2001 National Academy of Sciences, U.S.A. J:73485

Associated Alleles

Symbol	Name
Robo1^tm1Phr	roundabout guidance receptor 1; targeted mutation 1, Pamela H Rabbitts

Associated Genotypes

Allelic Composition	Genetic Background
Robo1^tm1Phr/Robo1^tm1Phr	involves: 129P2/OlaHsd * C57BL/6