Phenotype Image Detail

Image

Caption

A: Epidermis from a 2 day old Dsc1^tm1Dga/Dsc1^tm1Dga mouse showing hyperplasia and acantholysis. The granular layer appears to be separating from the upper spinous layer. B: Epidermis isolated from a 2 day old mutant mouse after treatment with EDTA showing that the tissue fragments allow only small pieces of epidermis to be separated from the dermis. C: Epidermis isolated using the same technique from a normal littermate. D: Ultrastructure of outer layers of epidermis from a normal mouse showing desmosomes (arrows). E: Ultrastructure of outer layers of epidermis from a mutant mouse with desmosomes (arrows) of a normal appearance. F: Ultrastructure of lesional epitelium in a mutant mouse showing splitting between cells and an absence of cell lysis. Arrows indicate possible remains of split desmosomes. All samples were from back skin. Bars: A, 20um; D and E, 1um; F, 2um.

Copyright

This image is from Chidgey M, J Cell Biol 2001 Nov 26;155(5):821-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:73102

Associated Alleles

Symbol	Name
Dsc1^tm1Dga	desmocollin 1; targeted mutation 1, David R Garrod

Associated Genotypes

Allelic Composition	Genetic Background
Dsc1^tm1Dga/Dsc1^tm1Dga	involves: C57BL/6J