Phenotype Image Detail

Image

Caption

A: Epidermis from a 2 day old wild type mouse. B: Epidermis from a Dsc1^tm1Dga/Dsc1^tm1Dga littermate showing hyperplasia. Bars (E) indicate thickness of living layers of epidermis. C: Epidermis from a mutant mouse showing localized hyperkeratosis and parakeratosis (retention of nuclei in the cornified layer) (arrow). D: Expression of Ki67 in the epidermis of a wild type mouse. E: Ki67 staining in the epidermis of a mutant mouse. Only one proliferating cell located in the basal layer is present in D (arrow), whereas in E almost all of the cells in the basal layer and numerous suprabasal cells (arrows) are undergoing cell division. A-C show head skin; D and E show back skin. Bars: A-C, 100um; D and E, 50um.

Copyright

This image is from Chidgey M, J Cell Biol 2001 Nov 26;155(5):821-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:73102

Associated Alleles

Symbol	Name
Dsc1^tm1Dga	desmocollin 1; targeted mutation 1, David R Garrod

Associated Genotypes

Allelic Composition	Genetic Background
Dsc1^tm1Dga/Dsc1^tm1Dga	involves: C57BL/6J