Phenotype Image Detail

Image

Caption

Electron micrographs of macroglial cells from wild type (A, C, and E) and Acp2^tm1Psa/Acp2^tm1Psa (B, D, and F) mice. A and B, astroglial cells. Immunoelectron microscopy for lamp-1 reveals labeling of a lysosome-like structure (arrow) in the wild type astrocyte (A), but a strong labeling of storage vacuoles (arrows) in the mutant astrocyte (B). C and D, Bergmann glial cells. Conventional electron microscopy of Bergmann glial cells demonstrates storage vacuoles (arrowheads) in mutant mice (D), which were absent in wild type (C). The storage vacuoles are partly filled with heterogeneously appearing material. E and F, ependymal cells. Conventional electron microscopy of ependymal cells reveals lysosomal storage (arrow) in mutant ependymal cells (F), which was not found in wild type (E). Scale bars: A and B, 1um; C and D, 0.5um; E and F, 1.5um.

Copyright

This image is from Saftig P, J Biol Chem 1997 Jul 25;272(30):18628-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:41986

Associated Alleles

Symbol	Name
Acp2^tm1Psa	acid phosphatase 2, lysosomal; targeted mutation 1, Paul Saftig

Associated Genotypes

Allelic Composition	Genetic Background
Acp2^tm1Psa/Acp2^tm1Psa	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J