Phenotype Image Detail

Image

Caption

Radiologic examination of wild type and Acp2^tm1Psa/Acp2^tm1Psa mice at 6 and 15 months of age. A and B: After an apparently normal development of the skeletal system, pathological alterations were first noted at the age of 6 months, when Acp2^tm1Psa/Acp2^tm1Psa mice (B) exhibited an augmented lower thoracic kyphosis and an upper thoracic lordosis of the vertebral column (arrowheads in B) as compared with wild type mice (A). At this stage, the overall bone structure appears otherwise normal. C-F: Until 15 months of age, mutant mice (D and F) have developed a considerable S-shaped deformation of the entire thoracic vertebral column and severe alterations of bone structure. Specifically, individual vertebral bodies feature an increased sagittal diameter (short arrows in E and F), whereby individual vertebral bodies exhibit a reduced axial height (indicated by arrowheads for LIII). In mutant mice, the pediculi of vertebral arches extend over almost the entire length of the corpus vertebrae (long arrows), thus leading to a dramatic reduction in size of the intervertebral foramina (small arrows pointing to intervertebral foramen LIV) and possiby to a compression of the corresponding spinal nerves. Wild type mice are shown in C and E.

Copyright

This image is from Saftig P, J Biol Chem 1997 Jul 25;272(30):18628-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:41986

Associated Alleles

Symbol	Name
Acp2^tm1Psa	acid phosphatase 2, lysosomal; targeted mutation 1, Paul Saftig

Associated Genotypes

Allelic Composition	Genetic Background
Acp2^tm1Psa/Acp2^tm1Psa	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J