Phenotype Image Detail

Image

Caption

Gross phenotype of Slc4a4^tm1Ges/Slc4a4^tm1Ges mice. A: Compared with gender-matched wild type (NBC1^+/+) littermates, 15 day old Slc4a4^tm1Ges/Slc4a4^tm1Ges mice exhibited growth retardation and emaciation. B: Body weights of mutant mice on day 13 were significantly reduced compared with wild type mcie (n = 12 +/+, 15 -/-; p < 3 x 10-7); mutants exhibited litte growth beyond that age, with fewer exceeding 7g. C: Survival curve for wild type and mutant mice. The precentage of surviving mice was plotted against age in days, with day 0 being the day of birth. Mutant mice exhibited a sharp decrease in mortality starting around 8 days of age with few mice surviving to 21 days of age (n = 153 for each genotype).

Copyright

This image is from Gawenis LR, J Biol Chem 2007 Mar 23;282(12):9042-52 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120867

Associated Alleles

Symbol	Name
Slc4a4^tm1Ges	solute carrier family 4 (anion exchanger), member 4; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a4^tm1Ges/Slc4a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss