Phenotype Image Detail

Image

Caption

Histology of the vestibular system. In the ampulla of the semicircular ducts of wild type (+/+, A), the gelatinous cupula (C) overlying the crista ampullaris (CA) sensory epithelium is bathed in endolymphatic fluid. In the Slc12a2^tm1Ges/Slc12a2^tm1Ges (-/-, B) ampulla, the epithelial lining that normally encloses the endolymph is collapsed upon the cupula. Remnants of trabeculae, strands of connective tissue cells that normally attach the epithelial lining of the semicircular duct to the bone, can be seen on both the basal surface of the epithelial lining and on the bone (B, upper left). In panel C, the wild type saccule otoconia (O), embedded in the gelatinous otolithic membrane (OM) that overlies the neuroepithelium of the macula (M), are bathed in endolymph. In the mutant saccule (D), the epithelial lining of the saccule has collapsed onto the otoconia. Scale bars: A, 80um; B, 100um; C and D, 50um.

Copyright

This image is from Flagella M, J Biol Chem 1999 Sep 17;274(38):26946-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:57651

Associated Alleles

Symbol	Name
Slc12a2^tm1Ges	solute carrier family 12, member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc12a2^tm1Ges/Slc12a2^tm1Ges	Not Specified
Slc12a2^tm1Ges/Slc12a2^tm1Ges	involves: NMRI
Slc12a2^tm1Ges/Slc12a2^tm1Ges	FVB.129(Cg)-Slc12a2^tm1Ges