Phenotype Image Detail

Image

Caption

Histology of toluidine blue-stained sections of oxyntic gastric glands from wild type and Atp4a^tm1Ges/Atp4a^tm1Ges stomach. A: Composite image of gastric glands from the corpus of an adult wild type stomach. Typical parietal cells are indicated by arrows. Chief cells with characteristic secretory granules were present at the base of the glands (arrowheads). B: Chief cells (arrowheads) and parietal cells (arrows) were also present in adult Atp4a^tm1Ges/Atp4a^tm1Ges gastric glands. Parietal cells had either numerous vacuole-like dilations (top arrow) or a single large dilation (bottom arrow). C: Severely dysplastic gastric glands from an adult mutant mouse, with chief cells (arrowhead), parietal cells with cytoplasmic dilations (arrow), and a large cyst surrounded by a single layer of a low cuboidal epithelium (double arrow). Scale bar: 50um.

Copyright

This image is from Spicer Z, J Biol Chem 2000 Jul 14;275(28):21555-65 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63470

Associated Alleles

Symbol	Name
Atp4a^tm1Ges	ATPase, H+/K+ exchanging, gastric, alpha polypeptide; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp4a^tm1Ges/Atp4a^tm1Ges	involves: 129X1/SvJ * Black Swiss