Phenotype Image Detail

Image

Caption

Coronal sections of wild type (+/+, A and C) and Pex2^tm1Plf/Pex2^tm1Plf (-/-, B and D) newborn mouse brains from medial (A and B) and ventral-lateral (C and D) cortical regions, stained with hematoxylin and eosin. The cortical layers in the wild type and "equivalent area" in the mutant are delimited by arrowheads: MZ, marginal zone; CP, cortical plate; SP, subplate. Note the abnormal cortical lamination in the mutant mouse (B) with a loss of distinction between the normal layer boundaries (indicated by white dotted lines in A) and an altered cell distribution, particularly in the layer V region. There is a reduction of intervening neuropil in the mutant (white circle in A shows normal neuropil). The lamination abnormalities are less severe in the ventral-lateral cortex (D). In this region, one can visualize the layer boundaries (C and D, white dotted lines), and the reduction in intervening neruopil is less severe (white circles). Scale bar: 31um.

Copyright

This image is from Faust PL, J Cell Biol 1997 Dec 1;139(5):1293-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:44975

Associated Alleles

Symbol	Name
Pex2^tm1Plf	peroxisomal biogenesis factor 2; targeted mutation 1, Phyllis L Faust

Associated Genotypes

Allelic Composition	Genetic Background
Pex2^tm1Plf/Pex2^tm1Plf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6